Mega Drive has fair-skin and raspberry-colored eyes. She has long blonde hair, worn with a small black clip with gold lining on three small buttons; each with an A, B, or C. Over her eyes is a pair of red oval glasses.
Mega Drive wears a short grey top with three, blue oval-shaped buttons, along with black denim shorts with a single silver button and large white cuffs. Inside of each pocket is violet coloring. Over her outfit, Mega Drive wears a black jacket lined in violet to match the inside coloring, while on each sleeve is a design to match her hair clip. At the collar and shoulder is a single, glowing oval blue design, while pinned to her chest is a gold badge. She wears black shoes with the same designs as on her jacket, along with thick white bottoms and a large, loose cuff.
Mega Drive is a cautious and very calculative person who prefers to make careful decisions and plans rather than immediately take action. Segami notes that due to this, awareness about video games have spread due to her actions. She also has pride that makes herself preventive on taking unfair actions.
Mega Drive was one of the three lead characters in the Hi☆sCoool! SeHa Girls anime, alongside Dreamcast and Sega Saturn.
In real life, the Sega Mega Drive is known as the Sega Genesis in other regions. Mega Drive retains her name however in the international releases of the Superdimension Neptune VS Sega Hard Girls. The reason is that a seperate character in the Sega Hard Girls series is based on the Genesis name, nicknamed "Jenny", who also cameos in the game as a NPC.